A study of peripheral leucocyte migration in agarose medium in inflammatory bowel disease.
نویسندگان
چکیده
THE MIGRATION OF PERIPHERAL LEUCOCYTES FROM PATIENTS WITH INFLAMMATORY BOWEL DISEASE WAS INVESTIGATED USING AN AGAROSE PLATE TECHNIQUE AND THREE ANTIGENIC MATERIALS: (1) the enterobacterial common antigen of Kunin; (2) extract from germ-free rat faeces; and (3) Kveim suspension from a sarcoid spleen K19. Inhibition of migration was obtained only with Kunin antigen. It was present in 11 out of 20 patients with ulcerative colitis and in four out of 20 patients with Crohn's disease but in only one out of 33 control subjects. These findings suggest the possibility that a state of cellular immunity to enterobacterial common antigen may exist in inflammatory bowel disease. Lack of cellular reactivity to extract from germ-free faeces and Kveim suspension is in contrast with the results obtained by others by means of the capillary tube method and requires further investigation.
منابع مشابه
Evaluation of Bcl2/BAX genes expression ratio as a marker of inflammatory bowel disease
Background: Apoptosis is an essential physiological process to maintain immune homeostasis. T-cell incorrect apoptosis appears to be involved in chronic inflammatory diseases such as inflammatory bowel disease (IBD). The aim of this study was to evaluate the Bcl2/BAX genes expression ratio in patients with IBD (Crohn’s disease and ulcerative colitis) compared to healthy persons. Materials and M...
متن کاملComparison of Coping Strategies in People with Inflammatory Bowel Disease and Healthy People in Terms of Health Locus of Control
Background: Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation (pain and swelling) in the intestines. IBD includes Crohn’s disease and ulcerative colitis. Both types affect the digestive system. The study aims to compare coping strategies in people with inflammatory bowel disease and healthy people, according to internal and external sources of health contr...
متن کاملLabelled leucocyte scintigraphy in inflammatory bowel disease: clinical applications.
Labelled leucocyte imaging is an established technique for the detection of inflammation and sepsis. Of the many radioisotopes used to label leucocytes, Indiuml1 tropolonate (11 1In) and Technetium-99m hexamethyl propylene amine oxime (99mTc HMPAO) are the most widely used. Leucocytes are obtained from heparinised, peripheral venous blood (40-100 ml) and then separated from erythrocytes and pla...
متن کاملThe Study of Upper Gastrointestinal Endoscopy in Patients with Inflammatory Bowel Disease and Ulcerative Colitis
Background and aims: In diagnosing inflammatory bowel disease, one of diagnostic way is upper gastrointestinal endoscopy, which helps in differential diagnosis of unspecified colitis as well. The aim of this study was to investigate the necessity of upper gastrointestinal endoscopy in patients with inflammatory bowel disease. Materials and Methods: In this descriptive cross-sectional...
متن کاملValidation of the Persian version of the inflammatory bowel disease questionnaire (IBDQ) in ulcerative colitis patients
Abstract Background: Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine that may have critical consequences on patient’s quality of life (QOL). Many disease-specific QOL tools have been developed recently. The McMaster Inflammatory Bowel Disease Questionnaire (IBDQ) is one of them. The aim of this study was to translate into Persian and eval...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Gut
دوره 15 4 شماره
صفحات -
تاریخ انتشار 1974